miR-21 Reduces Hydrogen Peroxide-Induced Apoptosis in c-kit(+) Cardiac Stem Cells In Vitro through PTEN/PI3K/Akt Signaling

The low survival rate of cardiac stem cells (CSCs) in the infarcted myocardium hampers cell therapy for ischemic cardiomyopathy. MicroRNA-21 (miR-21) and one of its target proteins, PTEN, contribute to the survival and proliferation of many cell types, but their prosurvival effects in c-kit(+) CSC r...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Deng, Wenwen, Wang, Yan, Long, Xianping, Zhao, Ranzun, Wang, Zhenglong, Liu, Zhijiang, Cao, Song, Shi, Bei
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075640/
https://ncbi.nlm.nih.gov/pubmed/27803763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5389181
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