Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice.

Oral administration of self-antigens has been proposed as a therapy to prevent and treat autoimmune diseases. Here we report that oral treatment with insulin prevents virus-induced insulin-dependent diabetes mellitus (IDDM) in a transgenic (tg) mouse model. Such mice express the viral nucleoprotein...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	von Herrath, M G, Dyrberg, T, Oldstone, M B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507558/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8823297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118919
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