A delta F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo.

The most prevalent mutation (delta F508) in cystic fibrosis patients inhibits maturation and transfer to the plasma membrane of the mutant cystic fibrosis transmembrane conductance regulator (CFTR). We have analyzed the properties of a delta F508 CFTR mouse model, which we described recently. We sho...

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Bibliografische gegevens
Hoofdauteurs: French, P J, van Doorninck, J H, Peters, R H, Verbeek, E, Ameen, N A, Marino, C R, de Jonge, H R, Bijman, J, Scholte, B J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1996
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC507556/
https://ncbi.nlm.nih.gov/pubmed/8823295
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