EGFR:GRB2 protein co-localization is a prognostic factor unrelated to overall EGFR expression or EGFR Mutation in Lung Adenocarcinoma

INTRODUCTION: Epidermal Growth Factor Receptor (EGFR) is a therapeutic target in Non-Small Cell Lung Cancer (NSCLC) for EGFR mutant patients. Proximity ligation assay (PLA) is a method to detect functional signaling associated protein complexes. GRB2 is an adaptor protein which binds to the phosphor...

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Publicado no:J Thorac Oncol
Main Authors: Toki, Maria I., Carvajal-Hausdorf, Daniel E., Altan, Mehmet, McLaughlin, Joseph, Henick, Brian, Schalper, Kurt, Syrigos, Konstantinos N., Rimm, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075503/
https://ncbi.nlm.nih.gov/pubmed/27449805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtho.2016.06.025
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