A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough

In spite of wide-spread vaccination, pertussis rates are rising in industrialized countries and remain high world-wide. With no specific therapeutics to treat disease, pertussis continues to cause considerable infant morbidity and mortality. The pertussis toxin is a major contributor to disease, res...

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Pubblicato in:Sci Transl Med
Autori principali: Nguyen, Annalee W., Wagner, Ellen K., Laber, Joshua R., Goodfield, Laura L., Smallridge, William E., Harvill, Eric T., Papin, James F., Wolf, Roman F., Padlan, Eduardo A., Bristol, Andy, Kaleko, Michael, Maynard, Jennifer A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075433/
https://ncbi.nlm.nih.gov/pubmed/26631634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad0966
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