A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough

In spite of wide-spread vaccination, pertussis rates are rising in industrialized countries and remain high world-wide. With no specific therapeutics to treat disease, pertussis continues to cause considerable infant morbidity and mortality. The pertussis toxin is a major contributor to disease, res...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Nguyen, Annalee W., Wagner, Ellen K., Laber, Joshua R., Goodfield, Laura L., Smallridge, William E., Harvill, Eric T., Papin, James F., Wolf, Roman F., Padlan, Eduardo A., Bristol, Andy, Kaleko, Michael, Maynard, Jennifer A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075433/
https://ncbi.nlm.nih.gov/pubmed/26631634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad0966
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