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Amino Acid Sensing in Skeletal Muscle

Aging impairs skeletal muscle protein synthesis, leading to muscle weakness and atrophy. However, the underlying molecular mechanisms remain poorly understood. Here, we review evidence that mTORC1- and ATF4-mediated amino acid sensing pathways, triggered by impaired amino acid delivery to aged skele...

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Bibliografski detalji
Izdano u:Trends Endocrinol Metab
Glavni autori: Moro, Tatiana, Ebert, Scott M., Adams, Christopher M., Rasmussen, Blake B.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075248/
https://ncbi.nlm.nih.gov/pubmed/27444066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2016.06.010
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