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Amino Acid Sensing in Skeletal Muscle

Aging impairs skeletal muscle protein synthesis, leading to muscle weakness and atrophy. However, the underlying molecular mechanisms remain poorly understood. Here, we review evidence that mTORC1- and ATF4-mediated amino acid sensing pathways, triggered by impaired amino acid delivery to aged skele...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Trends Endocrinol Metab
Prif Awduron: Moro, Tatiana, Ebert, Scott M., Adams, Christopher M., Rasmussen, Blake B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075248/
https://ncbi.nlm.nih.gov/pubmed/27444066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tem.2016.06.010
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