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Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

High-throughput phenotypic screening of chemical libraries has resulted in the identification of thousands of compounds with potent antimalarial activity, although in most cases, the mechanism(s) of action of these compounds remains unknown. Here we have investigated the mode of action of 90 antimal...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Creek, Darren J., Chua, Hwa H., Cobbold, Simon A., Nijagal, Brunda, MacRae, James I., Dickerman, Benjamin K., Gilson, Paul R., Ralph, Stuart A., McConville, Malcolm J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075070/
https://ncbi.nlm.nih.gov/pubmed/27572396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01226-16
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