Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action

High-throughput phenotypic screening of chemical libraries has resulted in the identification of thousands of compounds with potent antimalarial activity, although in most cases, the mechanism(s) of action of these compounds remains unknown. Here we have investigated the mode of action of 90 antimal...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Creek, Darren J., Chua, Hwa H., Cobbold, Simon A., Nijagal, Brunda, MacRae, James I., Dickerman, Benjamin K., Gilson, Paul R., Ralph, Stuart A., McConville, Malcolm J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075070/
https://ncbi.nlm.nih.gov/pubmed/27572396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01226-16
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