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Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo

Mycobacterium tuberculosis remains a global health threat largely due to the lengthy duration of curative antibiotic treatment, contributing to medical nonadherence and the emergence of drug resistance. This prolonged therapy is likely due to the presence of M. tuberculosis persisters, which exhibit...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Chuang, Yu-Min, Dutta, Noton K., Hung, Chien-Fu, Wu, T.-C., Rubin, Harvey, Karakousis, Petros C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075050/
https://ncbi.nlm.nih.gov/pubmed/27527086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01139-16
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