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Deficiency of the Novel Exopolyphosphatase Rv1026/PPX2 Leads to Metabolic Downshift and Altered Cell Wall Permeability in Mycobacterium tuberculosis

Mycobacterium tuberculosis can persist for decades in the human host. Stringent response pathways involving inorganic polyphosphate [poly(P)], which is synthesized and hydrolyzed by polyphosphate kinase (PPK) and exopolyphosphatase (PPX), respectively, are believed to play a key regulatory role in b...

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Publicat a:mBio
Autors principals: Chuang, Yu-Min, Bandyopadhyay, Nirmalya, Rifat, Dalin, Rubin, Harvey, Bader, Joel S., Karakousis, Petros C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4453511/
https://ncbi.nlm.nih.gov/pubmed/25784702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02428-14
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