PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers

BACKGROUND: Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF), but the mechanisms conveying their variable effectiveness are not known. Recent data suggested that paired like homeodomain-2 transcription factor (PITX2) might play an important role in regulating gene...

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Vydáno v:J Am Coll Cardiol
Hlavní autoři: Syeda, Fahima, Holmes, Andrew P., Yu, Ting Y., Tull, Samantha, Kuhlmann, Stefan Michael, Pavlovic, Davor, Betney, Daniel, Riley, Genna, Kucera, Jan P., Jousset, Florian, de Groot, Joris R., Rohr, Stephan, Brown, Nigel A., Fabritz, Larissa, Kirchhof, Paulus
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Biomedical 2016
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075046/
https://ncbi.nlm.nih.gov/pubmed/27765191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2016.07.766
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