No tolerance to peripheral morphine analgesia in presence of opioid expression in inflamed synovia.
Pain treatment with centrally acting opiates is limited by tolerance. Tolerance is a decreasing effect of a drug with prolonged administration of that drug or of a related (e.g., endogenous) compound acting at the same receptor. This is often associated with a downregulation of receptors. In periphe...
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| Published in: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
1996
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507490/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8698872/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118852 |
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