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No tolerance to peripheral morphine analgesia in presence of opioid expression in inflamed synovia.

Pain treatment with centrally acting opiates is limited by tolerance. Tolerance is a decreasing effect of a drug with prolonged administration of that drug or of a related (e.g., endogenous) compound acting at the same receptor. This is often associated with a downregulation of receptors. In periphe...

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Udgivet i:J Clin Invest
Principais autores: Stein, C, Pflüger, M, Yassouridis, A, Hoelzl, J, Lehrberger, K, Welte, C, Hassan, A H
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507490/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8698872/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118852
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