Structures of NS5 Methyltransferase from Zika Virus

The Zika virus (ZIKV) poses a major public health emergency. To aid in the development of antivirals, we present two high-resolution crystal structures of the ZIKV NS5 methyltransferase: one bound to S-adenosylmethionine (SAM) and the other bound to SAM and 7-methyl guanosine diphosphate (7-MeGpp)....

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發表在:Cell Rep
Main Authors: Coloma, Javier, Jain, Rinku, Rajashankar, Kanagalaghatta R., García-Sastre, Adolfo, Aggarwal, Aneel K.
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074680/
https://ncbi.nlm.nih.gov/pubmed/27633330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.08.091
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