Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

Insulin resistance (IR) and impaired insulin secretion contribute to type 2 diabetes and cardiovascular disease. Both are associated with changes in the circulating metabolome, but causal directions have been difficult to disentangle. We combined untargeted plasma metabolomics by liquid chromatograp...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Nowak, Christoph, Salihovic, Samira, Ganna, Andrea, Brandmaier, Stefan, Tukiainen, Taru, Broeckling, Corey D., Magnusson, Patrik K., Prenni, Jessica E., Wang-Sattler, Rui, Peters, Annette, Strauch, Konstantin, Meitinger, Thomas, Giedraitis, Vilmantas, Ärnlöv, Johan, Berne, Christian, Gieger, Christian, Ripatti, Samuli, Lind, Lars, Pedersen, Nancy L., Sundström, Johan, Ingelsson, Erik, Fall, Tove
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074591/
https://ncbi.nlm.nih.gov/pubmed/27768686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006379
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