Prostaglandin E(2) Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-α on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP()

The present study investigated the influence of PGE(2), E prostanoid (EP) receptors, and their signaling pathways on matrix metalloproteinase (MMP)-1 and IL-6 expression in synovial fibroblasts (SFs) from rheumatoid arthritis (RA) patients. RASFs expressed all four EP receptors, with selective induc...

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Pubblicato in:J Immunol
Autori principali: Kunisch, Elke, Jansen, Anne, Kojima, Fumiaki, Löffler, Ivonne, Kapoor, Mohit, Kawai, Shinichi, Rubio, Ignacio, Crofford, Leslie J., Kinne, Raimund W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074557/
https://ncbi.nlm.nih.gov/pubmed/19542367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0900801
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