Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis

Prostaglandin E synthase (PGES) including isoenzymes of membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES) is the recently identified terminal enzyme of the arachidonic acid cascade. PGES converts prostaglandin (PG)H(2 )to PGE(2 )downstream of cyclooxygenase (COX). We investigat...

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Detalhes bibliográficos
Main Authors: Kojima, Fumiaki, Naraba, Hiroaki, Miyamoto, Satoshi, Beppu, Moroe, Aoki, Haruhito, Kawai, Shinichi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC464891/
https://ncbi.nlm.nih.gov/pubmed/15225371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1195
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