Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality

Tat-interactive protein 60 (Tip60), encoded by the Kat5 gene, is a member of the MYST family of acetyltransferases. Cancer biology studies have shown that Tip60 induces the DNA damage response, apoptosis, and cell-cycle inhibition. Although Tip60 is expressed in the myocardium, its role in cardiomyo...

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Publicat a:PLoS One
Autors principals: Fisher, Joseph B., Horst, Audrey, Wan, Tina, Kim, Min-Su, Auchampach, John, Lough, John
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074524/
https://ncbi.nlm.nih.gov/pubmed/27768769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164855
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