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Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors.
Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507382/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675700/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118744 |
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