Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS

BACKGROUND: In the central nervous system regions of the sporadic and familial FTLD and ALS patients, TDP-43 has been identified as the major component of UBIs inclusions which is abnormally hyperphosphorylated, ubiquitinated, and cleaved into C-terminal fragments to form detergent-insoluble aggrega...

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Bibliographic Details
Published in:J Biomed Sci
Main Authors: Chang, Cheng-Fu, Lee, Yi-Chao, Lee, Kuen-Haur, Lin, Hui-Ching, Chen, Chia-Ling, Shen, Che-Kun James, Huang, Chi-Chen
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073438/
https://ncbi.nlm.nih.gov/pubmed/27769241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-016-0290-z
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