T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire

Factor VIII (FVIII)–neutralizing antibodies (“inhibitors”) are a serious problem in hemophilia A (HA). The aim of this study was to characterize HLA-restricted T-cell responses from a severe HA subject with a persistent inhibitor and from 2 previously studied mild HA inhibitor subjects. Major histoc...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Ettinger, Ruth A., Paz, Pedro, James, Eddie A., Gunasekera, Devi, Aswad, Fred, Thompson, Arthur R., Matthews, Dana C., Pratt, Kathleen P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073183/
https://ncbi.nlm.nih.gov/pubmed/27471234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-682468
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