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Tense your megas! Structural rigidity is key

In this issue of Blood, Aguilar et al demonstrate that megakaryocytes adapt to the “stiffness” of their microenvironment and that re-creating the physical constraints encountered in native bone marrow dramatically improves in vitro megakaryocyte differentiation and proplatelet formation.(1)

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Blood
Päätekijä: Psaila, Bethan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5073178/
https://ncbi.nlm.nih.gov/pubmed/28157674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-734509
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