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Tense your megas! Structural rigidity is key
In this issue of Blood, Aguilar et al demonstrate that megakaryocytes adapt to the “stiffness” of their microenvironment and that re-creating the physical constraints encountered in native bone marrow dramatically improves in vitro megakaryocyte differentiation and proplatelet formation.(1)
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| Udgivet i: | Blood |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5073178/ https://ncbi.nlm.nih.gov/pubmed/28157674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-734509 |
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