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Decreased fetal hemoglobin over time among youth with sickle cell disease on hydroxyurea is associated with higher urgent hospital use

BACKGROUND: Hydroxyurea (HU) induces dose-dependent increased fetal hemoglobin (HbF) for sickle cell disease (SCD). Large deviation from historical personal best (PBest) HbF, a clinic-based version of maximum dose, may identify a subset with suboptimal HU adherence over time. PROCEDURE: Retrospectiv...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Green, Nancy S., Manwani, Deepa, Qureshi, Mahvish, Ireland, Karen, Sinha, Arpan, Smaldone, Arlene M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072999/
https://ncbi.nlm.nih.gov/pubmed/27573582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.26161
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