Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits. In vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner.

Lecithin cholesterol acyltransferase (LCAT) is an enzyme involved in the intravascular metabolism of high density lipoproteins (HDLs). Overexpression of human LCAT (hLCAT) in transgenic rabbits leads to gene dose-dependent increases of total and HDL cholesterol concentrations. To elucidate the mecha...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Brousseau, M E, Santamarina-Fojo, S, Zech, L A, Bérard, A M, Vaisman, B L, Meyn, S M, Powell, D, Brewer, H B, Hoeg, J M
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507252/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8621767/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118614
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