Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways

BACKGROUND: In high-grade serous ovarian cancer (HGSOC), intrinsic and/or acquired resistance against platinum-containing chemotherapy is a major obstacle for successful treatment. A low frequency of somatic mutations but frequent epigenetic alterations, including DNA methylation in HGSOC tumors, pr...

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Bibliografiske detaljer
Udgivet i:	Genome Med
Main Authors:	Tomar, Tushar, de Jong, Steven, Alkema, Nicolette G., Hoekman, Rieks L., Meersma, Gert Jan, Klip, Harry G., van der Zee, Ate GJ, Wisman, G. Bea A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2016
Fag:	Research
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5072346/ https://ncbi.nlm.nih.gov/pubmed/27765068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0361-5
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Genome-wide methylation profiling of ovarian cancer patient-derived xenografts treated with the demethylating agent decitabine identifies novel epigenetically regulated genes and pathways

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