Robotic QM/MM-driven maturation of antibody combining sites

In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibod...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Smirnov, Ivan V., Golovin, Andrey V., Chatziefthimiou, Spyros D., Stepanova, Anastasiya V., Peng, Yingjie, Zolotareva, Olga I., Belogurov, Alexey A., Kurkova, Inna N., Ponomarenko, Natalie A., Wilmanns, Matthias, Blackburn, G. Michael, Gabibov, Alexander G., Lerner, Richard A.
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072179/
https://ncbi.nlm.nih.gov/pubmed/27774510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501695
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