Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma

Immunotherapy approaches for pancreatic ductal adenocarcinoma (PDAC) have met with limited success. It has been postulated that a low mutation load may lead to a paucity of T cells within the tumor microenvironment (TME). However, it is also possible that while neoantigens are present, an effective...

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Publicat a:Sci Rep
Autors principals: Bailey, Peter, Chang, David K., Forget, Marie-Andrée, Lucas, Francis A. San, Alvarez, Hector A., Haymaker, Cara, Chattopadhyay, Chandrani, Kim, Sun-Hee, Ekmekcioglu, Suhendan, Grimm, Elizabeth A., Biankin, Andrew V., Hwu, Patrick, Maitra, Anirban, Roszik, Jason
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071896/
https://ncbi.nlm.nih.gov/pubmed/27762323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35848
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