Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase()()

A number of clinical trials have shown that KRAS mutations of colorectal cancer (CRC) can predict a lack of responses to anti-epidermal growth factor receptor–based therapy. Recently, there have been several studies to elucidate metabolism reprogramming in cancer. However, it remains to be investiga...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Toda, Kosuke, Kawada, Kenji, Iwamoto, Masayoshi, Inamoto, Susumu, Sasazuki, Takehiko, Shirasawa, Senji, Hasegawa, Suguru, Sakai, Yoshiharu
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2016
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071549/
https://ncbi.nlm.nih.gov/pubmed/27764698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2016.09.004
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