The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression

The growth factor receptor/PI3K/AKT pathway is an important drug target in many cancers including Glioblastoma. AKT, a key node in the pathway, has 3 isoforms, AKT1, AKT2 and AKT3. Here we investigate their role in GBM. We find each activated, ser473 phosphorylated isoform is present in some GBMs bu...

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Foilsithe in:J Neurooncol
Main Authors: Joy, Anna, Kapoor, Manisha, Georges, Joseph, Butler, Lacy, Chang, Yongchang, Li, Chaokun, Crouch, Acacia, Smirnov, Ivan, Nakada, Mitsitoshi, Hepler, James, Marty, Max, Feuerstein, Burt G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5071179/
https://ncbi.nlm.nih.gov/pubmed/27422127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-016-2220-z
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