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AKT Pathway Genes Define 5 Prognostic Subgroups in Glioblastoma
Activity of GFR/PI3K/AKT pathway inhibitors in glioblastoma clinical trials has not been robust. We hypothesized variations in the pathway between tumors contribute to poor response. We clustered GBM based on AKT pathway genes and discovered new subtypes then characterized their clinical and molecul...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4077731/ https://ncbi.nlm.nih.gov/pubmed/24984002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100827 |
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