PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis

Mutations of the Plekhm1 gene in humans and rats cause osteopetrosis, an inherited bone disease characterized by diminished bone resorption by osteoclasts. PLEKHM1 binds to RAB7 and is critical for lysosome trafficking. However, the molecular mechanisms by which PLEKHM1 regulates lysosomal pathways...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Fujiwara, Toshifumi, Ye, Shiqiao, Castro-Gomes, Thiago, Winchell, Caylin G., Andrews, Norma W., Voth, Daniel E., Varughese, Kottayil I., Mackintosh, Samuel G., Feng, Yunfeng, Pavlos, Nathan, Nakamura, Takashi, Manolagas, Stavros C., Zhao, Haibo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070964/
https://ncbi.nlm.nih.gov/pubmed/27777970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86330
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