Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast

Adaptive evolution plays a large role in generating the phenotypic diversity observed in nature, yet current methods are impractical for characterizing the molecular basis and fitness effects of large numbers of individual adaptive mutations. Here we used a DNA barcoding approach to generate the gen...

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Vydáno v:Cell
Hlavní autoři: Venkataram, Sandeep, Dunn, Barbara, Li, Yuping, Agarwala, Atish, Chang, Jessica, Ebel, Emily, Geiler-Samerotte, Kerry, Herissant, Lucas, Blundell, Jamie, Levy, Sasha F., Fisher, Daniel S., Sherlock, Gavin, Petrov, Dmitri A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070919/
https://ncbi.nlm.nih.gov/pubmed/27594428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.002
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