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The dynamics of adaptive genetic diversity during the early stages of clonal evolution
The dynamics of genetic diversity in large clonally evolving cell populations are poorly understood, despite having implications for the treatment of cancer and microbial infections. Here, we combine barcode lineage tracking, sequencing of adaptive clones and mathematical modelling of mutational dyn...
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| Publicado no: | Nat Ecol Evol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6517070/ https://ncbi.nlm.nih.gov/pubmed/30598529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41559-018-0758-1 |
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