Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs

The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer’s dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B(12), methionine and homocysteine. However, the existence or physiological signi...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Guzzo, Marissa B., Nguyen, Hoa T., Pham, Thanh H., Wyszczelska-Rokiel, Monika, Jakubowski, Hieronim, Wolff, Kerstin A., Ogwang, Sam, Timpona, Joseph L., Gogula, Soumya, Jacobs, Michael R., Ruetz, Markus, Kräutler, Bernhard, Jacobsen, Donald W., Zhang, Guo-Fang, Nguyen, Liem
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070874/
https://ncbi.nlm.nih.gov/pubmed/27760199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005949
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