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Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs

The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer’s dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B(12), methionine and homocysteine. However, the existence or physiological signi...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Guzzo, Marissa B., Nguyen, Hoa T., Pham, Thanh H., Wyszczelska-Rokiel, Monika, Jakubowski, Hieronim, Wolff, Kerstin A., Ogwang, Sam, Timpona, Joseph L., Gogula, Soumya, Jacobs, Michael R., Ruetz, Markus, Kräutler, Bernhard, Jacobsen, Donald W., Zhang, Guo-Fang, Nguyen, Liem
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070874/
https://ncbi.nlm.nih.gov/pubmed/27760199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005949
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