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Bacterial Conversion of Folinic Acid Is Required for Antifolate Resistance
Antifolates, which are among the first antimicrobial agents invented, inhibit cell growth by creating an intracellular state of folate deficiency. Clinical resistance to antifolates has been mainly attributed to mutations that alter structure or expression of enzymes involved in de novo folate synth...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3083218/ https://ncbi.nlm.nih.gov/pubmed/21372133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.231076 |
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