Potentiation of TRAIL killing activity by multimerization through isoleucine zipper hexamerization motif

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a homo-trimeric cytotoxic ligand. Several studies have demonstrated that incorporation of artificial trimerization motifs into the TRAIL protein leads to the enhancement of biological activity. Here, we show that linkage of the...

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Bibliographic Details
Published in:BMB Rep
Main Authors: Han, Ji Hye, Moon, Ae Ran, Chang, Jeong Hwan, Bae, Jeehyeon, Choi, Jin Myung, Lee, Sung Haeng, Kim, Tae-Hyoung
Format: Artigo
Language:Inglês
Published: Korean Society for Biochemistry and Molecular Biology 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070708/
https://ncbi.nlm.nih.gov/pubmed/26674343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.5.245
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