Potentiation of TRAIL killing activity by multimerization through isoleucine zipper hexamerization motif

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a homo-trimeric cytotoxic ligand. Several studies have demonstrated that incorporation of artificial trimerization motifs into the TRAIL protein leads to the enhancement of biological activity. Here, we show that linkage of the...

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Detalhes bibliográficos
Publicado no:BMB Rep
Main Authors: Han, Ji Hye, Moon, Ae Ran, Chang, Jeong Hwan, Bae, Jeehyeon, Choi, Jin Myung, Lee, Sung Haeng, Kim, Tae-Hyoung
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070708/
https://ncbi.nlm.nih.gov/pubmed/26674343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.5.245
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