Increased delta aminolevulinic acid and decreased pineal melatonin production. A common event in acute porphyria studies in the rat.

Tryptophan (TRP) is the precursor of melatonin, the primary secretory product of the pineal gland. Hepatic heme deficiency decreases the activity of liver tryptophan pyrrolase, leading to increased plasma TRP and serotonin. As a paradox, patients with attacks of acute intermittent porphyria (AIP), e...

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Autores principales: Puy, H, Deybach, J C, Bogdan, A, Callebert, J, Baumgartner, M, Voisin, P, Nordmann, Y, Touitou, Y
Formato: Artigo
Lenguaje:Inglês
Publicado: 1996
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC507067/
https://ncbi.nlm.nih.gov/pubmed/8550820
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