Heme Biosynthesis in Intermittent Acute Porphyria: Decreased Hepatic Conversion of Porphobilinogen to Porphyrins and Increased Delta Aminolevulinic Acid Synthetase Activity

Hepatic conversion of porphobilinogen to porphyrins was less than 50% of control levels in human subjects with the genetic disease, intermittent acute porphyria. This relative block in heme biosynthesis may be relevant to a concomitant 6- to 10-fold elevation in δ-aminolevulinic acid synthetase acti...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Strand, L. James, Felsher, Bertram F., Redeker, Allan G., Marver, Harvey S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1970
Assuntos:	Biological Sciences: Medical Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC283354/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/5274461/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.67.3.1315
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