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Modifications of myelin basic protein in DM20 transgenic mice are similar to those in myelin basic protein from multiple sclerosis.

Transgenic mice containing different numbers of transgenes (2-70) of the myelin proteolipid protein DM20 were phenotypically normal up to 3 mo of age, after which the mice containing 70 copies of the transgene spontaneously demyelinated and died at 10-12 mo. Since we demonstrated that demyelination...

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Published in:J Clin Invest
Main Authors: Mastronardi, F G, Mak, B, Ackerley, C A, Roots, B I, Moscarello, M A
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507024/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8567954/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118422
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