Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

BACKGROUND: Relapsed acute lymphoblastic leukemia (ALL) is one of the main causes of mortality in childhood malignancies. Previous genetic studies demonstrated that chemoresistant ALL is driven by activating mutations in NT5C2, the gene encoding cytosolic 5´-nucleotidase (cN-II). However, molecular...

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Detalhes bibliográficos
Publicado no:BMC Biol
Main Authors: Hnízda, Aleš, Škerlová, Jana, Fábry, Milan, Pachl, Petr, Šinalová, Martina, Vrzal, Lukáš, Man, Petr, Novák, Petr, Řezáčová, Pavlína, Veverka, Václav
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070119/
https://ncbi.nlm.nih.gov/pubmed/27756303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-016-0313-y
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