MUC20 Suppresses the Hepatocyte Growth Factor-Induced Grb2-Ras Pathway by Binding to a Multifunctional Docking Site of Met

A cDNA encoding a novel mucin protein, MUC20, was isolated as a gene that is up-regulated in the renal tissues of patients with immunoglobulin A nephropathy. We demonstrate here that the C terminus of MUC20 associates with the multifunctional docking site of Met without ligand activation, preventing...

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Bibliographische Detailangaben
Hauptverfasser: Higuchi, Toshio, Orita, Takuya, Katsuya, Ken, Yamasaki, Yoshiki, Akiyama, Kiyotaka, Li, Huiping, Yamamoto, Tadashi, Saito, Yutaka, Nakamura, Motonao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC506992/
https://ncbi.nlm.nih.gov/pubmed/15314156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7456-7468.2004
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