Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing

BACKGROUND: Targeted next generation sequencing (tNGS) has become part of molecular pathology diagnostics for determining RAS mutation status in colorectal cancer (CRC) patients as predictive tool for decision on EGFR-targeted therapy. Here, we investigated mutation profiles of case-matched tissue s...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Kovaleva, Valentina, Geissler, Anna-Lena, Lutz, Lisa, Fritsch, Ralph, Makowiec, Frank, Wiesemann, Sebastian, Hopt, Ulrich T., Passlick, Bernward, Werner, Martin, Lassmann, Silke
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069823/
https://ncbi.nlm.nih.gov/pubmed/27756406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0549-8
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