A Semi-Physiological Population Model to Quantify the Effect of Hematocrit on Everolimus Pharmacokinetics and Pharmacodynamics in Cancer Patients

INTRODUCTION AND OBJECTIVE: Everolimus (a drug from the class of mammalian target of rapamycin [mTOR] inhibitors) is associated with frequent toxicity-related dose reductions. Everolimus accumulates in erythrocytes, but the extent to which hematocrit affects everolimus plasma pharmacokinetics and ph...

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Udgivet i:Clin Pharmacokinet
Main Authors: van Erp, Nielka P., van Herpen, Carla M., de Wit, Djoeke, Willemsen, Annelieke, Burger, David M., Huitema, Alwin D. R., Kapiteijn, Ellen, ter Heine, Rob
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2016
Fag:
Original Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069307/
https://ncbi.nlm.nih.gov/pubmed/27299325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-016-0414-3
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