Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662

AIMS: Previously published pharmacokinetic (PK) models for sunitinib and its active metabolite SU12662 were based on a limited dataset or lacked important elements such as correlations between sunitinib and its metabolite. The current study aimed to develop an improved PK model that circumvented the...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Yu, Huixin, Steeghs, Neeltje, Kloth, Jacqueline S L, de Wit, Djoeke, van Hasselt, J G Coen, van Erp, Nielka P, Beijnen, Jos H, Schellens, Jan H M, Mathijssen, Ron H J, Huitema, Alwin D R
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415717/
https://ncbi.nlm.nih.gov/pubmed/25393890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12550
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