Bmi1 Loss in the Organ of Corti Results in p16(ink4a) Upregulation and Reduced Cell Proliferation of Otic Progenitors In Vitro

The mature mammalian organ of Corti does not regenerate spontaneously after injury, mainly due to the absence of cell proliferation and the depletion of otic progenitors with age. The polycomb gene B lymphoma Mo-MLV insertion region 1 homolog (Bmi1) promotes proliferation and cell cycle progression...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Bassiouni, Mohamed, Dos Santos, Aurélie, Avci, Hasan X., Löwenheim, Hubert, Müller, Marcus
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068820/
https://ncbi.nlm.nih.gov/pubmed/27755610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164579
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